First comprehensive single cell transcriptomic atlas of the human parietal pleura published

January 29, 2024

We are very pleased to announce that the Mesobank team, in collaboration with other groups, has recently published in the European Respiratory Journal our latest completed research project “Single-cell transcriptomic analysis of human pleura reveals stromal heterogeneity and informs in vitro models of mesothelioma” . In this publication, we present the first comprehensive single cell transcriptomic atlas of the human parietal pleura and identify its cellular components, describing its stromal populations and fibroblast subtypes. This atlas enabled us to prolong mesothelial cell differentiation in vitro, maintaining their characteristic morphology and transcriptomic phenotype. We also compared our atlas with in vitro pleura and mesothelioma models, revealing phenotypic groups.

 

Additionally, we have opened the Mesothelial Cell Atlas, an online data mining tool created as a collaboration between Mesobank, the University of Cambridge and Yale School of Medicine, that allows users to explore this novel dataset interactively at mesothelialcellatlas.com. We anticipate that our pleural cell atlas will be a valuable resource for researchers studying pleural biology and disease.